Supplementation of non-fermented and fermented goji berry (Lycium barbarum) improves hepatic function and corresponding lipid metabolism via their anti-inflammatory and antioxidant properties in high fat-fed rats

Abstract Development of obesity is associated with excessive fat accumulation and oxidative stress along chronic inflammation. Goji berries ( Lycium barbarum ) are high in polyphenolic compounds have anti-inflammatory, anti-oxidant, hypolipidemic properties that may alleviate the pathogenesis related metabolic complications. Thus, aim this study was to investigate potential benefits GB supplementation against (HF) diet-induced its comorbidities HF diet-fed rats (male Sprague–Dawley, n = 8/group, 6 weeks old). We also sought examine fermented (FGB) L. plantarum CB3 possible distinctions degree and/or mechanism action compared GB. FGB suppressed gene expression inflammation indices at local (adipose tissues) systemic (liver) levels. In addition, upregulated antioxidant enzymes even low (LF) group more remarkable effects by supplementation. Also, protected from HF-induced damages liver dyslipidemia. conclusion, we demonstrated complications primarily improving hepatic function corresponding lipid metabolism via their anti-inflammatory properties. To our knowledge, first vivo confirming a form. these findings support application both ameliorate obesity-associated abnormalities.